Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC2254304 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Journal of molecular biology 20070929 3
The AcrAB multidrug efflux pump, which belongs to the resistance nodulation division (RND) family, recognizes and extrudes a wide range of antibiotics and chemotherapeutic agents and causes the intrinsic antibiotic resistance in Escherichia coli. The expression of AcrAB is controlled by the transcriptional regulator AcrR, whose open reading frame is located 141 bp upstream of the acrAB operon. To understand the structural basis of AcrR regulation, we have determined the crystal structure of AcrR ...[more]