A new method for the evaluation of vaccine safety based on comprehensive gene expression analysis.
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ABSTRACT:
SUBMITTER: Momose H
PROVIDER: S-EPMC2896671 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Publications
A new method for the evaluation of vaccine safety based on comprehensive gene expression analysis.
Momose Haruka H Mizukami Takuo T Ochiai Masaki M Hamaguchi Isao I Yamaguchi Kazunari K
Journal of biomedicine & biotechnology 20100613
For the past 50 years, quality control and safety tests have been used to evaluate vaccine safety. However, conventional animal safety tests need to be improved in several aspects. For example, the number of test animals used needs to be reduced and the test period shortened. It is, therefore, necessary to develop a new vaccine evaluation system. In this review, we show that gene expression patterns are well correlated to biological responses in vaccinated rats. Our findings and methods using ex ...[more]
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