Cytokine-induced monocyte characteristics in SLE.
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ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC2896681 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Publications
Cytokine-induced monocyte characteristics in SLE.
Zhang Zhe Z Maurer Kelly K Perin Juan C JC Song Li L Sullivan Kathleen E KE
Journal of biomedicine & biotechnology 20100624
Monocytes in SLE have been described as having aberrant behavior in a number of assays. We examined gene expression and used a genome-wide approach to study the posttranslational histone mark, H4 acetylation, to examine epigenetic changes in SLE monocytes. We compared SLE monocyte gene expression and H4 acetylation with three types of cytokine-treated monocytes to understand which cytokine effects predominated in SLE monocytes. We found that gamma-interferon and alpha-interferon both replicated ...[more]
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