Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC2896713 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Journal of biomedicine & biotechnology 20100610
DNA vaccination can induce specific CD8(+) T cell immune response, but the response level is low in large mammals and human beings. Coadministration of an adjuvant can optimize protective immunity elicited by a DNA vaccine. In this study, we investigated the effect of a synthetic glucohexaose (beta-glu6), an analogue of Lentinan basic unit, on specific CD8(+) T cell response induced by a DNA vaccine encoding HBcAg (pB144) in mice. We found that beta-glu6 promoted the recruitment and maturation o ...[more]