Ontology highlight
ABSTRACT:
SUBMITTER: Cherry CM
PROVIDER: S-EPMC2897240 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Cherry Christopher M CM Matunis Erika L EL
Cell stem cell 20100601 6
Regulation of stem cells depends on both tissue-specific transcriptional regulators and changes in chromatin organization, yet the coordination of these events in endogenous niches is poorly understood. In the Drosophila testis, local JAK-STAT signaling maintains germline and somatic stem cells (GSCs and cyst progenitor cells, or CPCs) in a single niche. Here we show that epigenetic regulation via the nucleosome-remodeling factor (NURF) complex ensures GSC and CPC maintenance by positively regul ...[more]