Ontology highlight
ABSTRACT:
SUBMITTER: Inaba M
PROVIDER: S-EPMC3210491 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Inaba Mayu M Yuan Hebao H Yamashita Yukiko M YM
Development (Cambridge, England) 20111026 23
Tight regulation of stem cell proliferation is fundamental to tissue homeostasis, aging and tumor suppression. Although stem cells are characterized by their high potential to proliferate throughout the life of the organism, the mechanisms that regulate the cell cycle of stem cells remain poorly understood. Here, we show that the Cdc25 homolog String (Stg) is a crucial regulator of germline stem cells (GSCs) and cyst stem cells (CySCs) in Drosophila testis. Through knockdown and overexpression e ...[more]