Ontology highlight
ABSTRACT:
SUBMITTER: Imwong M
PROVIDER: S-EPMC2897287 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Imwong Mallika M Dondorp Arjen M AM Nosten Francois F Yi Poravuth P Mungthin Mathirut M Hanchana Sarun S Das Debashish D Phyo Aung Phae AP Lwin Khin Maung KM Pukrittayakamee Sasithon S Lee Sue J SJ Saisung Suwannee S Koecharoen Kitti K Nguon Chea C Day Nicholas P J NP Socheat Duong D White Nicholas J NJ
Antimicrobial agents and chemotherapy 20100426 7
The reduced in vivo sensitivity of Plasmodium falciparum has recently been confirmed in western Cambodia. Identifying molecular markers for artemisinin resistance is essential for monitoring the spread of the resistant phenotype and identifying the mechanisms of resistance. Four candidate genes, including the P. falciparum mdr1 (pfmdr1) gene, the P. falciparum ATPase6 (pfATPase6) gene, the 6-kb mitochondrial genome, and ubp-1, encoding a deubiquitinating enzyme, of artemisinin-resistant P. falci ...[more]