Ontology highlight
ABSTRACT:
SUBMITTER: Rawat M
PROVIDER: S-EPMC7806804 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Rawat Mukul M Kanyal Abhishek A Sahasrabudhe Aishwarya A Vembar Shruthi Sridhar SS Lopez-Rubio Jose-Juan JJ Karmodiya Krishanpal K
Scientific reports 20210113 1
Plasmodium falciparum has evolved resistance to almost all front-line drugs including artemisinin, which threatens malaria control and elimination strategies. Oxidative stress and protein damage responses have emerged as key players in the generation of artemisinin resistance. In this study, we show that PfGCN5, a histone acetyltransferase, binds to the stress-responsive genes in a poised state and regulates their expression under stress conditions. Furthermore, we show that upon artemisinin exp ...[more]