Ontology highlight
ABSTRACT:
SUBMITTER: Xu R
PROVIDER: S-EPMC2897825 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Xu Rui R Ekiert Damian C DC Krause Jens C JC Hai Rong R Crowe James E JE Wilson Ian A IA
Science (New York, N.Y.) 20100325 5976
The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human H1N1 viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epito ...[more]