Comparison of three commercially available dengue NS1 antigen capture assays for acute diagnosis of dengue in Brazil.

ABSTRACT:

Background

Dengue is associated with explosive urban epidemics and has become a major public health problem in many tropical developing countries, including Brazil. The laboratory diagnosis of dengue can be carried out using several approaches, however sensitive and specific assays useful to diagnose in the early stage of fever are desirable. The flavivirus non-structural protein NS1, a highly conserved and secreted glycoprotein, is a candidate protein for rapid diagnosis of dengue in endemic countries.

Methodology/principal findings

We aimed to evaluate the potential use of 3 commercial kits in a panel of 450 serum samples for early diagnosis of dengue in Brazil. The PanBio Early ELISA (PanBio Diagnostics) showed a sensitivity of 72.3% (159/220) and a specificity of 100%, w

SUBMITTER: Lima Mda R 

PROVIDER: S-EPMC2897844 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature