Ontology highlight
ABSTRACT:
SUBMITTER: Georges GE
PROVIDER: S-EPMC2897972 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Georges George E GE Lesnikov Vladimir V Baran Szczepan W SW Aragon Anna A Lesnikova Marina M Jordan Robert R Laura Yang Ya-Ju YJ Yunusov Murad Y MY Zellmer Eustacia E Heimfeld Shelly S Venkataraman Gopalakrishnan M GM Harkey Michael A MA Graves Scott S SS Storb Rainer R Storer Barry E BE Nash Richard A RA
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20100318 8
Cord blood transplantation (CBT) with units containing total nucleated cell (TNC) dose >2.5 x 10(7)/kg is associated with improved engraftment and decreased transplant-related mortality. For many adults no single cord blood units are available that meet the cell dose requirements. We developed a dog model of CBT to evaluate approaches to overcome the problem of low cell dose cord blood units. This study primarily compared double- versus single-unit CBT. Unrelated dogs were bred and cord blood un ...[more]