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A preclinical model of double- versus single-unit unrelated cord blood transplantation.


ABSTRACT: Cord blood transplantation (CBT) with units containing total nucleated cell (TNC) dose >2.5 x 10(7)/kg is associated with improved engraftment and decreased transplant-related mortality. For many adults no single cord blood units are available that meet the cell dose requirements. We developed a dog model of CBT to evaluate approaches to overcome the problem of low cell dose cord blood units. This study primarily compared double- versus single-unit CBT. Unrelated dogs were bred and cord blood units were harvested. We identified unrelated recipients that were dog leukocyte antigen (DLA)-88 (class I) and DLA-DRB1 (class II) allele-matched with cryopreserved units. Each unit contained

SUBMITTER: Georges GE 

PROVIDER: S-EPMC2897972 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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A preclinical model of double- versus single-unit unrelated cord blood transplantation.

Georges George E GE   Lesnikov Vladimir V   Baran Szczepan W SW   Aragon Anna A   Lesnikova Marina M   Jordan Robert R   Laura Yang Ya-Ju YJ   Yunusov Murad Y MY   Zellmer Eustacia E   Heimfeld Shelly S   Venkataraman Gopalakrishnan M GM   Harkey Michael A MA   Graves Scott S SS   Storb Rainer R   Storer Barry E BE   Nash Richard A RA  

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20100318 8


Cord blood transplantation (CBT) with units containing total nucleated cell (TNC) dose >2.5 x 10(7)/kg is associated with improved engraftment and decreased transplant-related mortality. For many adults no single cord blood units are available that meet the cell dose requirements. We developed a dog model of CBT to evaluate approaches to overcome the problem of low cell dose cord blood units. This study primarily compared double- versus single-unit CBT. Unrelated dogs were bred and cord blood un  ...[more]

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