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Distinct biological network properties between the targets of natural products and disease genes.

ABSTRACT: We show that natural products target proteins with a high number of protein-protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential biological pathways, resulting in competitor death. This result also suggests that additional sources of small molecules will be required to discover drugs targeting the root causes of human disease in the future.

SUBMITTER: Dancik V

PROVIDER: S-EPMC2898216 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Distinct biological network properties between the targets of natural products and disease genes.

Dancík Vlado V Seiler Kathleen Petri KP Young Damian W DW Schreiber Stuart L SL Clemons Paul A PA

Journal of the American Chemical Society 20100701 27

We show that natural products target proteins with a high number of protein-protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential biological pathways, resulting in competitor death. This result also suggests that additional sources of small molecules will be required to discover drugs targeting the root causes of human disease in the future. ...[more]

PMID: 20565092

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