Ontology highlight
ABSTRACT:
SUBMITTER: Chambliss KL
PROVIDER: S-EPMC2898582 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Chambliss Ken L KL Wu Qian Q Oltmann Sarah S Konaniah Eddy S ES Umetani Michihisa M Korach Kenneth S KS Thomas Gail D GD Mineo Chieko C Yuhanna Ivan S IS Kim Sung Hoon SH Madak-Erdogan Zeynep Z Maggi Adriana A Dineen Sean P SP Roland Christina L CL Hui David Y DY Brekken Rolf A RA Katzenellenbogen John A JA Katzenellenbogen Benita S BS Shaul Philip W PW
The Journal of clinical investigation 20100623 7
Steroid hormone receptors function classically in the nucleus as transcription factors. However, recent data indicate that there are also non-nuclear subpopulations of steroid hormone receptors, including estrogen receptors (ERs), that mediate membrane-initiated signaling of unclear basis and significance. Here we have shown that an estrogen-dendrimer conjugate (EDC) that is excluded from the nucleus stimulates endothelial cell proliferation and migration via ERalpha, direct ERalpha-Galphai inte ...[more]