Tie2-Cre-Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury.
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ABSTRACT:
SUBMITTER: Liu PY
PROVIDER: S-EPMC9911321 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
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Tie2-Cre-Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury.
Liu Pang-Yen PY Fukuma Nobuaki N Hiroi Yukio Y Kunita Akiko A Tokiwa Hiroyuki H Ueda Kazutaka K Kariya Taro T Numata Genri G Adachi Yusuke Y Tajima Miyu M Toyoda Masayuki M Li Yuxin Y Noma Kensuke K Harada Mutsuo M Toko Haruhiro H Ushiku Tetsuo T Kanai Yoshimitsu Y Takimoto Eiki E Liao James K JK Komuro Issei I
JACC. Basic to translational science 20221116 1
Using the Cre-loxP system, we generated the first mouse model in which estrogen receptor-α non-nuclear signaling was inactivated in endothelial cells. Estrogen protection against mechanical vascular injury was impaired in this model. This result indicates the pivotal role of endothelial estrogen receptor-α non-nuclear signaling in the vasculoprotective effects of estrogen. ...[more]
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