Ontology highlight
ABSTRACT:
SUBMITTER: Eke I
PROVIDER: S-EPMC2898588 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Eke Iris I Koch Ulrike U Hehlgans Stephanie S Sandfort Veit V Stanchi Fabio F Zips Daniel D Baumann Michael M Shevchenko Anna A Pilarsky Christian C Haase Michael M Baretton Gustavo B GB Calleja Véronique V Larijani Banafshé B Fässler Reinhard R Cordes Nils N
The Journal of clinical investigation 20100607 7
Tumor cell resistance to ionizing radiation and chemotherapy is a major obstacle in cancer therapy. One factor contributing to this is integrin-mediated adhesion to ECM. The adapter protein particularly interesting new cysteine-histidine-rich 1 (PINCH1) is recruited to integrin adhesion sites and promotes cell survival, but the mechanisms underlying this effect are not well understood. Here we have shown that PINCH1 is expressed at elevated levels in human tumors of diverse origins relative to n ...[more]