Dataset Information

Activation of AhR with nuclear IKK? regulates cancer stem-like properties in the occurrence of radioresistance.

ABSTRACT: Most cancer patients receive radiotherapy in the course of their disease and the occurrence of radioresistance is associated with poor prognosis. The molecular pathways that drive enhanced tumorigenic potential during the development of radioresistance are poorly understood. Here, we demonstrate that aryl hydrocarbon receptor (AhR) plays a vital role in the maintenance of cancer stem-like properties. AhR promotes the cancer stem-like phenotype and drives metastasis by directly targeting the promoters of 'stemness' genes, such as the ATP-binding cassette sub-family G member 2 (ABCG2) gene. Moreover, the radioresistant sublines display high levels of oncometabolites including ?-ketoglutarate, and treatment of cancer cells with ?-ketoglutarate enhances their stem-like properties in an AhR activation-dependent manner. IKK? directly activates stemness-related genes through an interaction with AhR as a bone fide chromatin modifier. Thus, AhR is functionally linked with cancer stem-like properties, and it drives tumorigenesis in the occurrence of radioresistance.

SUBMITTER: Yan B

PROVIDER: S-EPMC5924755 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance.

Yan Bin B Liu Shuang S Shi Ying Y Liu Na N Chen Ling L Wang Xiang X Xiao Desheng D Liu Xiaoli X Mao Chao C Jiang Yiqun Y Lai Weiwei W Xin Xing X Tang Can-E CE Luo Dixian D Tan Tan T Jia Jiantao J Liu Yating Y Yang Rui R Huang Jun J Zhou Hu H Cheng Yan Y Cao Ya Y Yu Weishi W Muegge Kathrin K Tao Yongguang Y

Cell death & disease 20180501 5

Most cancer patients receive radiotherapy in the course of their disease and the occurrence of radioresistance is associated with poor prognosis. The molecular pathways that drive enhanced tumorigenic potential during the development of radioresistance are poorly understood. Here, we demonstrate that aryl hydrocarbon receptor (AhR) plays a vital role in the maintenance of cancer stem-like properties. AhR promotes the cancer stem-like phenotype and drives metastasis by directly targeting the prom ...[more]

PMID: 29706625

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Dataset Information

Activation of AhR with nuclear IKK? regulates cancer stem-like properties in the occurrence of radioresistance.

Publications

Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance.

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