Large-scale analysis of network bistability for human cancers.
Ontology highlight
ABSTRACT:
SUBMITTER: Shiraishi T
PROVIDER: S-EPMC2900289 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Publications
Large-scale analysis of network bistability for human cancers.
Shiraishi Tetsuya T Matsuyama Shinako S Kitano Hiroaki H
PLoS computational biology 20100708 7
Protein-protein interaction and gene regulatory networks are likely to be locked in a state corresponding to a disease by the behavior of one or more bistable circuits exhibiting switch-like behavior. Sets of genes could be over-expressed or repressed when anomalies due to disease appear, and the circuits responsible for this over- or under-expression might persist for as long as the disease state continues. This paper shows how a large-scale analysis of network bistability for various human can ...[more]
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