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Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities.

ABSTRACT: We investigated N-adamantyl-N'-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive compounds acting in vivo.

SUBMITTER: Kasagami T

PROVIDER: S-EPMC2900318 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature

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Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities.

Kasagami Takeo T Kim In-Hae IH Tsai Hsing-Ju HJ Nishi Kosuke K Hammock Bruce D BD Morisseau Christophe C

Bioorganic & medicinal chemistry letters 20090127 6

We investigated N-adamantyl-N'-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive compounds acting in vivo. ...[more]

PMID: 19216074

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