Association between IRF6 SNPs and oral clefts in West China.
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ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC2901597 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Association between IRF6 SNPs and oral clefts in West China.
Huang Y Y Wu J J Ma J J Beaty T H TH Sull J W JW Zhu L L Lu D D Wang Y Y Meng T T Shi B B
Journal of dental research 20090801 8
Analyses of previous data have confirmed the contribution of the IRF6 gene to susceptibility to non- syndromic oral clefts (NSOC) in some populations. We tested for associations between the rs2013162, rs2235375, and rs2235371 polymorphisms in IRF6 and the risk of NSOC, using both case-parent trio and case-control designs on samples from western China. Our study group consisted of 332 persons with NSOC, their parents (289 mothers and 243 fathers for 206 complete trios for these three SNPs), and 1 ...[more]
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