Ontology highlight
ABSTRACT:
SUBMITTER: Morissette MR
PROVIDER: S-EPMC2901846 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Morissette Michael R MR Cook Stuart A SA Foo ShiYin S McKoy Godfrina G Ashida Noboru N Novikov Mikhail M Scherrer-Crosbie Marielle M Li Ling L Matsui Takashi T Brooks Gavin G Rosenzweig Anthony A
Circulation research 20060608 1
Myostatin is a highly conserved, potent negative regulator of skeletal muscle hypertrophy in many species, from rodents to humans, although its mechanisms of action are incompletely understood. Transcript profiling of hearts from a genetic model of cardiac hypertrophy revealed dramatic upregulation of myostatin, not previously recognized to play a role in the heart. Here we show that myostatin abrogates the cardiomyocyte growth response to phenylephrine in vitro through inhibition of p38 and the ...[more]