Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC2903248 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Li Jianhua J Lin Shanshan S Chen Qiying Q Peng Lu L Zhai Jianwei J Liu Yinghui Y Yuan Zhenghong Z
Journal of virology 20100421 13
Myeloid differentiation primary response protein 88 (MyD88), which can be induced by alpha interferon (IFN-alpha), has an antiviral activity against the hepatitis B virus (HBV). The mechanism of this antiviral activity remains poorly understood. Here, we report that MyD88 inhibited HBV replication in HepG2.2.15 cells and in a mouse model. The knockdown of MyD88 expression weakened the IFN-alpha-induced inhibition of HBV replication. Furthermore, MyD88 posttranscriptionally reduced the levels of ...[more]