Ontology highlight
ABSTRACT:
SUBMITTER: Barnitz RA
PROVIDER: S-EPMC2903295 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Journal of virology 20100414 13
Infection with human immunodeficiency virus type 1 (HIV-1) causes an inexorable depletion of CD4(+) T cells. The loss of these cells is particularly pronounced in the mucosal immune system during acute infection, and the data suggest that direct viral cytopathicity is a major factor. Cell cycle arrest caused by the HIV-1 accessory protein Vpr is strongly correlated with virus-induced cell death, and phosphorylation of Vpr serine 79 (S79) is required to activate G(2)/M cell cycle blockade. Howeve ...[more]