Ontology highlight
ABSTRACT:
SUBMITTER: Papantonis A
PROVIDER: S-EPMC2903595 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Papantonis Argyris A Larkin Joshua D JD Wada Youichiro Y Ohta Yoshihiro Y Ihara Sigeo S Kodama Tatsuhiko T Cook Peter R PR
PLoS biology 20100713 7
It is widely assumed that active RNA polymerases track along their templates to produce a transcript. We test this using chromosome conformation capture and human genes switched on rapidly and synchronously by tumour necrosis factor alpha (TNFalpha); one is 221 kbp SAMD4A, which a polymerase takes more than 1 h to transcribe. Ten minutes after stimulation, the SAMD4A promoter comes together with other TNFalpha-responsive promoters. Subsequently, these contacts are lost as new downstream ones app ...[more]