Ontology highlight
ABSTRACT:
SUBMITTER: Rosales T
PROVIDER: S-EPMC3674427 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Rosales Tilman T Nie Zuqin Z Kapoor Varun V Casellas Rafael R Knutson Jay R JR Levens David D
Scientific reports 20130101
Myc levels are highly regulated and usually low in vivo. Dimerized with Max, it regulates most expressed genes and so directly and indirectly controls most cellular processes. Intranuclear diffusion of a functional c-Myc-eGFP, expressed from its native locus in murine fibroblasts and 3T3 cells or by transient transfection, was monitored using Two Photon Fluorescence Correlation Spectroscopy, revealing concentration and size (mobility) of complexes. With increased c-Myc-eGFP, a very immobile pool ...[more]