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Construction of 5,6-Ring Fused 2-Pyridones: An Effective Annulation Tactic Achieved in Water.

ABSTRACT: An efficient protocol for elaboration of the 5,6-fused 2-pyridone ring system, exploiting the tandem condensation of propiolamide and cyclic ?-ketomethyl esters in water, followed by acid or base promoted intramolecular ring closure and decarboxylation, has been developed.

SUBMITTER: Smith AB

PROVIDER: S-EPMC2904244 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

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Construction of 5,6-Ring Fused 2-Pyridones: An Effective Annulation Tactic Achieved in Water.

Smith Amos B AB Atasoylu Onur O Beshore Douglas C DC

Synlett : accounts and rapid communications in synthetic organic chemistry 20090101 16

An efficient protocol for elaboration of the 5,6-fused 2-pyridone ring system, exploiting the tandem condensation of propiolamide and cyclic β-ketomethyl esters in water, followed by acid or base promoted intramolecular ring closure and decarboxylation, has been developed. ...[more]

PMID: 20634903

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