Ontology highlight
ABSTRACT:
SUBMITTER: Berg V
PROVIDER: S-EPMC3665338 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Berg Veronica V Das Pralay P Chorell Erik E Hedenström Mattias M Pinkner Jerome S JS Hultgren Scott J SJ Almqvist Fredrik F
Bioorganic & medicinal chemistry letters 20080507 12
Ring-fused 2-pyridones, termed pilicides, are small synthetic compounds that inhibit pilus assembly in uropathogenic Escherichia coli. Their biological activity is clearly dependent upon a carboxylic acid functionality. Here, we present the synthesis and biological evaluation of carboxylic acid isosteres, including, for example, tetrazoles, acyl sulfonamides, and hydroxamic acids of two lead 2-pyridones. Two independent biological evaluations show that acyl sulfonamides and tetrazoles significan ...[more]