Ontology highlight
ABSTRACT:
SUBMITTER: Gregory MA
PROVIDER: S-EPMC2904512 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Gregory Mark A MA Phang Tzu L TL Neviani Paolo P Alvarez-Calderon Francesca F Eide Christopher A CA O'Hare Thomas T Zaberezhnyy Vadym V Williams Richard T RT Druker Brian J BJ Perrotti Danilo D Degregori James J
Cancer cell 20100701 1
Although Bcr-Abl kinase inhibitors have proven effective in the treatment of chronic myeloid leukemia (CML), they generally fail to eradicate Bcr-Abl(+) leukemia cells. To identify genes whose inhibition sensitizes Bcr-Abl(+) leukemias to killing by Bcr-Abl inhibitors, we performed an RNAi-based synthetic lethal screen with imatinib mesylate in CML cells. This screen identified numerous components of a Wnt/Ca(2+)/NFAT signaling pathway. Antagonism of this pathway led to impaired NFAT activity, d ...[more]