Ontology highlight
ABSTRACT:
SUBMITTER: Gifford LK
PROVIDER: S-EPMC2905464 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Gifford Lida K LK Sendroiu Iuliana E IE Corn Robert M RM Lupták Andrej A
Journal of the American Chemical Society 20100701 27
DNA microarrays are invaluable tools for biosensing applications such as diagnostic detection of DNA and analysis of gene expression. Surface plasmon resonance imaging can detect unlabeled oligonucleotide targets adsorbed to the array elements. The variety of biosensing applications can be expanded by enzymatic manipulation of DNA microarray elements, and the sensitivity of detection can be enhanced with the use of oligonucleotide immobilized onto a gold nanoparticle surface. We describe a novel ...[more]