Ontology highlight
ABSTRACT:
SUBMITTER: Muhlenberg T
PROVIDER: S-EPMC2905726 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Mühlenberg Thomas T Zhang Yixiang Y Wagner Andrew J AJ Grabellus Florian F Bradner James J Taeger Georg G Lang Hauke H Taguchi Takahiro T Schuler Martin M Fletcher Jonathan A JA Bauer Sebastian S
Cancer research 20090825 17
Gastrointestinal stromal tumors (GIST) are characterized by activating mutations of KIT or platelet-derived growth factor receptor A (PDGFRA), and treatment with the tyrosine kinase inhibitor imatinib yields responses in the majority of patients. However, most patients develop secondary resistance, which is associated with a dismal prognosis. Histone deacetylase inhibitors (HDACI) have been shown to enhance imatinib activity in imatinib-resistant chronic myelogenous leukemia. Against this backgr ...[more]