Ontology highlight
ABSTRACT:
SUBMITTER: Atay S
PROVIDER: S-EPMC3896203 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Atay Safinur S Banskota Samagya S Crow Jennifer J Sethi Geetika G Rink Lori L Godwin Andrew K AK
Proceedings of the National Academy of Sciences of the United States of America 20131230 2
During tumor development, constant interplay occurs between tumor cells and surrounding stromal cells. We report evidence that gastrointestinal stromal tumor (GIST) cells invade the interstitial stroma through the release of the oncogenic protein tyrosine kinase (KIT)-containing exosomes, which triggers the phenotypic conversion of progenitor smooth muscle cells to tumor-promoting cells. These recipient cells display morphologic changes and acquire tumor-associated phenotypes, including enhanced ...[more]