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Antiproliferative bistramides from Trididemnum cyclops from Madagascar (1).

ABSTRACT: Bioassay-guided fractionation of a marine extract from Trididemnum cyclops afforded the new lipopeptide 39-oxobistramide K (1) and the known bistramides A (2) and D (3). Structure elucidation of 1 was carried out by analysis of one- and two-dimensional NMR spectroscopy and HRMS data. Bistramides have been reported to exhibit antiproliferative activity in the nanomolar range against a number of tumor cell lines in vitro and in vivo. The isolate 1 was tested for antiproliferative activity against the A2780 cell line and exhibited an IC(50) value of 0.34 microM.

SUBMITTER: Murphy BT

PROVIDER: S-EPMC2905825 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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Antiproliferative bistramides from Trididemnum cyclops from Madagascar (1).

Murphy Brian T BT Cao Shugeng S Brodie Peggy P Maharavo Jean J Andriamanantoanina Hanta H Ravelonandro Pierre P Kingston David G I DG

Journal of natural products 20090701 7

Bioassay-guided fractionation of a marine extract from Trididemnum cyclops afforded the new lipopeptide 39-oxobistramide K (1) and the known bistramides A (2) and D (3). Structure elucidation of 1 was carried out by analysis of one- and two-dimensional NMR spectroscopy and HRMS data. Bistramides have been reported to exhibit antiproliferative activity in the nanomolar range against a number of tumor cell lines in vitro and in vivo. The isolate 1 was tested for antiproliferative activity against ...[more]

PMID: 19555084

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