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Antiproliferative triterpenoid saponins of Dodonaea viscosa from the Madagascar dry forest.

ABSTRACT: Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Dodonaea viscosa led to the isolation of two new antiproliferative oleanane-type triterpenoid saponins, dodoneasides A and B (1 and 2). The structures of these two new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1 and 2 showed antiproliferative activity against the A2780 human ovarian cancer cell line with IC(50) values of 0.79 and 0.70 muM, respectively.

SUBMITTER: Cao S

PROVIDER: S-EPMC2930020 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Antiproliferative triterpenoid saponins of Dodonaea viscosa from the Madagascar dry forest.

Cao Shugeng S Brodie Peggy P Callmander Martin M Randrianaivo Richard R Razafitsalama Jeremi J Rakotobe Etienne E Rasamison Vincent E VE TenDyke Karen K Shen Yongchun Y Suh Edward M EM Kingston David G I DG

Journal of natural products 20090901 9

Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Dodonaea viscosa led to the isolation of two new antiproliferative oleanane-type triterpenoid saponins, dodoneasides A and B (1 and 2). The structures of these two new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1 and 2 showed antiproliferative activity against the A2780 human ovarian cancer cell line with IC(50) values of 0.79 and 0.70 muM, respectively ...[more]

PMID: 19719093

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