Ontology highlight
ABSTRACT:
SUBMITTER: Finegan KG
PROVIDER: S-EPMC2906708 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Finegan Katherine G KG Tournier Cathy C
Cancer research 20100707 14
The mitogen-activated protein kinase (MAPK) kinase 4 (MKK4) is a nonredundant component of stress-activated MAPK signaling modules. Its function in tumorigenesis remains highly controversial with some studies indicating that MKK4 is a tumor suppressor, whereas others have reported a pro-oncogenic role. To clarify the role of MKK4 in cancer, we have created a novel mouse model to test the effect of the specific loss of MKK4 in the epidermis on the formation of papillomas caused by activated ras m ...[more]