Ontology highlight
ABSTRACT:
SUBMITTER: Donohoe F
PROVIDER: S-EPMC7072904 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Donohoe Fionán F Wilkinson Michael M Baxter Eva E Brennan Donal J DJ
International journal of molecular sciences 20200213 4
Obesity is a major public health concern worldwide. The increased risk of certain types of cancer is now an established deleterious consequence of obesity, although the molecular mechanisms of this are not completely understood. In this review, we aim to explore the links between MAPK signalling and obesity-related cancer. We focus mostly on p38 and JNK MAPK, as the role of ERK remains unclear. These links are seen through the implication of MAPK in obesity-related immune paralysis as well as th ...[more]