Ontology highlight
ABSTRACT:
SUBMITTER: Abe S
PROVIDER: S-EPMC2907559 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Abe Satoshi S Tanaka Hiromi H Notsu Tomomi T Horike Shin-Ichi S Fujisaki Chikako C Qi Dong-Lai DL Ohhira Takahito T Gilley David D Oshimura Mitsuo M Kugoh Hiroyuki H
Genome integrity 20100526 1
Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA. The reactivation of telomerase activity by aberrant upregulation/expression of its catalytic subunit hTERT is a major pathway in human tumorigenesis. However, regulatory mechanisms that control hTERT expression are largely unknown. Previously, we and others have demonstrated that the introduction of human chromosome 3, via microcell-mediated chromosome transfer (MMCT), repressed transcription of the hTERT gene. These result ...[more]