Ontology highlight
ABSTRACT:
SUBMITTER: Yamashita S
PROVIDER: S-EPMC5892129 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Journal of biochemistry 20160615 5
The human telomerase reverse transcriptase (hTERT) gene encodes an enzyme responsible for maintaining the integrity of chromosomal ends. hTERT plays a key role in cellular immortalization, tumorigenesis and the progression of cancer. Previously, we reported that hTERT repression is required for the induction of cellular senescence. Thus, transcriptional regulation mechanisms of the hTERT gene may be related to the mechanisms of cellular senescence. In the present study, we clarified the molecula ...[more]