Ontology highlight
ABSTRACT:
SUBMITTER: Shi S
PROVIDER: S-EPMC2907674 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Shi Shuqun S Hida Akiko A McGuinness Owen P OP Wasserman David H DH Yamazaki Shin S Johnson Carl Hirschie CH
Current biology : CB 20100211 4
Most of the central circadian clock genes in the mouse exist as paralog pairs (Per1 and Per2, Cry1 and Cry2, Clock and Npas2) in which each gene of the pair must be knocked out to confer arrhythmicity. The only exception to this pattern is Bmal1 (also known as Mop3), the single knockout of which confers arrhythmicity, despite the presence of its paralog, Bmal2 (also known as Mop9). The knockout of Bmal1 also has significant effects on longevity, metabolism, etc. These results have led to the con ...[more]