Ontology highlight
ABSTRACT:
SUBMITTER: Lee EK
PROVIDER: S-EPMC2908492 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Lee Eun Kyung EK Kim Hyeon Ho HH Kuwano Yuki Y Abdelmohsen Kotb K Srikantan Subramanya S Subaran Sarah S SS Gleichmann Marc M Mughal Mohamed R MR Martindale Jennifer L JL Yang Xiaoling X Worley Paul F PF Mattson Mark P MP Gorospe Myriam M
Nature structural & molecular biology 20100516 6
Amyloid precursor protein (APP) regulates neuronal synapse function, and its cleavage product Abeta is linked to Alzheimer's disease. Here, we present evidence that the RNA-binding proteins (RBPs) heterogeneous nuclear ribonucleoprotein (hnRNP) C and fragile X mental retardation protein (FMRP) associate with the same APP mRNA coding region element, and they influence APP translation competitively and in opposite directions. Silencing hnRNP C increased FMRP binding to APP mRNA and repressed APP t ...[more]