Ontology highlight
ABSTRACT:
SUBMITTER: Majumder P
PROVIDER: S-EPMC5073124 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Majumder Pritha P Chu Jen-Fei JF Chatterjee Biswanath B Swamy Krishna B S KB Shen Che-Kun James CJ
Acta neuropathologica 20160812 5
For proper mammalian brain development and functioning, the translation of many neuronal mRNAs needs to be repressed without neuronal activity stimulations. We have discovered that the expression of a subclass of neuronal proteins essential for neurodevelopment and neuron plasticity is co-regulated at the translational level by TDP-43 and the Fragile X Syndrome protein FMRP. Using molecular, cellular and imaging approaches, we show that these two RNA-binding proteins (RBP) co-repress the transla ...[more]