Ontology highlight
ABSTRACT:
SUBMITTER: Stacey SN
PROVIDER: S-EPMC2908678 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Stacey Simon N SN Sulem Patrick P Zanon Carlo C Gudjonsson Sigurjon A SA Thorleifsson Gudmar G Helgason Agnar A Jonasdottir Aslaug A Besenbacher Soren S Kostic Jelena P JP Fackenthal James D JD Huo Dezheng D Adebamowo Clement C Ogundiran Temidayo T Olson Janet E JE Fredericksen Zachary S ZS Wang Xianshu X Look Maxime P MP Sieuwerts Anieta M AM Martens John W M JW Pajares Isabel I Garcia-Prats Maria D MD Ramon-Cajal Jose M JM de Juan Ana A Panadero Angeles A Ortega Eugenia E Aben Katja K H KK Vermeulen Sita H SH Asadzadeh Fatemeh F van Engelenburg K C Anton KC Margolin Sara S Shen Chen-Yang CY Wu Pei-Ei PE Försti Asta A Lenner Per P Henriksson Roger R Johansson Robert R Enquist Kerstin K Hallmans Göran G Jonsson Thorvaldur T Sigurdsson Helgi H Alexiusdottir Kristin K Gudmundsson Julius J Sigurdsson Asgeir A Frigge Michael L ML Gudmundsson Larus L Kristjansson Kristleifur K Halldorsson Bjarni V BV Styrkarsdottir Unnur U Gulcher Jeffrey R JR Hemminki Kari K Lindblom Annika A Kiemeney Lambertus A LA Mayordomo Jose I JI Foekens John A JA Couch Fergus J FJ Olopade Olufunmilayo I OI Gudbjartsson Daniel F DF Thorsteinsdottir Unnur U Rafnar Thorunn T Johannsson Oskar T OT Stefansson Kari K
PLoS genetics 20100722 7
We used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor alpha (ESR1) genes. We identified a panel of SNPs that are correlated with rs2046210 in Chinese, but not necessarily so in other ancestral populations, and genotyped them in breast cancer case:control samples of Asian ...[more]