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ABSTRACT: Objective
We hypothesized that insulin detemir mixed with aspart had equivalent effects on blood glucose as if being given as separate injections in pediatric type 1 diabetes patients.Research design and methods
Fourteen children with type 1 diabetes were randomly assigned to either Study A (mixed insulins) or Study B (separate insulins) for the first 10 days and crossed over for the last 10 days. Each subject underwent continuous glucose monitoring on the last 72 h of each study.Results
The 48-h area under the curve (mmol/hour/l), M-value, and mean amplitude of glucose excursion (mmol/l) for Study A versus Study B were 457 +/- 70 versus 469 +/- 112 (P = 0.58), 39.67 +/- 15.37 versus 39.75 +/- 9.69 (P = 0.98), and 6.35 +/- 1.92 versus 5.98 +/- 0.92 (P = 0.42), respectively.Conclusions
Insulin detemir mixed with aspart had equivalent effects on blood glucose versus giving them as separate injections in children with type 1 diabetes.
SUBMITTER: Nguyen TM
PROVIDER: S-EPMC2909056 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Nguyen Thanh M TM Renukuntla Venkat S VS Heptulla Rubina A RA
Diabetes care 20100526 8
<h4>Objective</h4>We hypothesized that insulin detemir mixed with aspart had equivalent effects on blood glucose as if being given as separate injections in pediatric type 1 diabetes patients.<h4>Research design and methods</h4>Fourteen children with type 1 diabetes were randomly assigned to either Study A (mixed insulins) or Study B (separate insulins) for the first 10 days and crossed over for the last 10 days. Each subject underwent continuous glucose monitoring on the last 72 h of each study ...[more]