Ontology highlight
ABSTRACT:
SUBMITTER: Abhary S
PROVIDER: S-EPMC2909072 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Abhary Sotoodeh S Burdon Kathryn P KP Laurie Kate J KJ Thorpe Stacey S Landers John J Goold Lucy L Lake Stewart S Petrovsky Nikolai N Craig Jamie E JE
Diabetes care 20100427 8
<h4>Objective</h4>Aldose reductase (ALR) is involved in diabetic microvascular damage via the polyol pathway. A recent meta-analysis found genetic variation in the ALR gene (AKR1B1) to be significantly associated with diabetic retinopathy (DR). We investigated the genetic association of AKR1B1 with DR.<h4>Research design and methods</h4>The study enrolled 909 individuals with diabetes. Participants were genotyped for an AKR1B1 (CA)n microsatellite and 14 tag single nucleotide polymorphisms, and ...[more]