Ontology highlight
ABSTRACT:
SUBMITTER: Wu M
PROVIDER: S-EPMC2909470 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Wu Mingfu M Smith Christopher L CL Hall James A JA Lee Ivy I Luby-Phelps Kate K Tallquist Michelle D MD
Developmental cell 20100701 1
During heart morphogenesis, epicardial cells undergo an epithelial-to-mesenchymal transition (EMT) and migrate into the subepicardium. The cellular signals controlling this process are poorly understood. Here, we show that epicardial cells exhibit two distinct mitotic spindle orientations, directed either parallel or perpendicular to the basement membrane. Cells undergoing perpendicular cell division subsequently enter the myocardium. We found that loss of beta-catenin led to a disruption of adh ...[more]