Ontology highlight
ABSTRACT:
SUBMITTER: Machicoane M
PROVIDER: S-EPMC4068135 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
The Journal of cell biology 20140601 6
Mitotic spindle orientation relies on a complex dialog between the spindle microtubules and the cell cortex, in which F-actin has been recently implicated. Here, we report that the membrane-actin linkers ezrin/radixin/moesin (ERMs) are strongly and directly activated by the Ste20-like kinase at mitotic entry in mammalian cells. Using microfabricated adhesive substrates to control the axis of cell division, we found that the activation of ERMs plays a key role in guiding the orientation of the mi ...[more]