Regulation of microRNA expression and abundance during lymphopoiesis.
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ABSTRACT:
SUBMITTER: Kuchen S
PROVIDER: S-EPMC2909788 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Regulation of microRNA expression and abundance during lymphopoiesis.
Kuchen Stefan S Resch Wolfgang W Yamane Arito A Kuo Nan N Li Zhiyu Z Chakraborty Tirtha T Wei Lai L Laurence Arian A Yasuda Tomoharu T Peng Siying S Hu-Li Jane J Lu Kristina K Dubois Wendy W Kitamura Yoshiaki Y Charles Nicolas N Sun Hong-wei HW Muljo Stefan S Schwartzberg Pamela L PL Paul William E WE O'Shea John J Rajewsky Klaus K Casellas Rafael R
Immunity 20100603 6
Although the cellular concentration of miRNAs is critical to their function, how miRNA expression and abundance are regulated during ontogeny is unclear. We applied miRNA-, mRNA-, and ChIP-Seq to characterize the microRNome during lymphopoiesis within the context of the transcriptome and epigenome. We show that lymphocyte-specific miRNAs are either tightly controlled by polycomb group-mediated H3K27me3 or maintained in a semi-activated epigenetic state prior to full expression. Because of miRNA ...[more]
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