Ontology highlight
ABSTRACT:
SUBMITTER: Kredo-Russo S
PROVIDER: S-EPMC3362837 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Experimental diabetes research 20120517
Genome-encoded microRNAs (miRNAs) provide a posttranscriptional regulatory layer, which is important for pancreas development. Differentiation of endocrine cells is controlled by a network of pancreatic transcription factors including Ngn3 and NeuroD/Beta2. However, how specific miRNAs are intertwined into this transcriptional network is not well understood. Here, we characterize the regulation of microRNA-7 (miR-7) by endocrine-specific transcription factors. Our data reveal that three independ ...[more]