Ontology highlight
ABSTRACT:
SUBMITTER: Staals RH
PROVIDER: S-EPMC2910272 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Staals Raymond H J RH Bronkhorst Alfred W AW Schilders Geurt G Slomovic Shimyn S Schuster Gadi G Heck Albert J R AJ Raijmakers Reinout R Pruijn Ger J M GJ
The EMBO journal 20100608 14
The exosome is an exoribonuclease complex involved in the degradation and maturation of a wide variety of RNAs. The nine-subunit core of the eukaryotic exosome is catalytically inactive and may have an architectural function and mediate substrate binding. In Saccharomyces cerevisiae, the associated Dis3 and Rrp6 provide the exoribonucleolytic activity. The human exosome-associated Rrp6 counterpart contributes to its activity, whereas the human Dis3 protein is not detectably associated with the e ...[more]