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Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes.

ABSTRACT: An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor ( p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.

SUBMITTER: Zavaleta C

PROVIDER: S-EPMC2910584 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature

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Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes.

Zavaleta C C de la Zerda A A Liu Z Z Keren S S Cheng Z Z Schipper M M Chen X X Dai H H Gambhir S S SS

Nano letters 20080807 9

An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor ( p < 0.05) as opposed to plain-SWNTs. These results support the de ...[more]

PMID: 18683988

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