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Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.

ABSTRACT: The gram-scale isolation of the major flavonolignan diastereoisomers from milk thistle ( Silybum marianum) extract provided an entree into the isolation of two related analogues that are present in extremely minute quantities. The isolation and structure elucidation of these two new compounds, which we have termed isosilybin C and isosilybin D due to their structural similarities to isosilybin A and isosilybin B, respectively, afforded a preliminary analysis of structure-activity relationships toward prostate cancer growth, survival, and apoptotic endpoints.

SUBMITTER: Sy-Cordero A

PROVIDER: S-EPMC2910627 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.

Sy-Cordero Arlene A Graf Tyler N TN Nakanishi Yuka Y Wani Mansukh C MC Agarwal Rajesh R Kroll David J DJ Oberlies Nicholas H NH

Planta medica 20091125 6

The gram-scale isolation of the major flavonolignan diastereoisomers from milk thistle ( Silybum marianum) extract provided an entree into the isolation of two related analogues that are present in extremely minute quantities. The isolation and structure elucidation of these two new compounds, which we have termed isosilybin C and isosilybin D due to their structural similarities to isosilybin A and isosilybin B, respectively, afforded a preliminary analysis of structure-activity relationships t ...[more]

PMID: 19941262

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