S100A4 regulates macrophage chemotaxis.
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ABSTRACT:
SUBMITTER: Li ZH
PROVIDER: S-EPMC2912347 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
S100A4 regulates macrophage chemotaxis.
Li Zhong-Hua ZH Dulyaninova Natalya G NG House Reniqua P RP Almo Steven C SC Bresnick Anne R AR
Molecular biology of the cell 20100602 15
S100A4, a member of the S100 family of Ca(2+)-binding proteins, is directly involved in tumor metastasis. In addition to its expression in tumor cells, S100A4 is expressed in normal cells and tissues, including fibroblasts and cells of the immune system. To examine the contribution of S100A4 to normal physiology, we established S100A4-deficient mice by gene targeting. Homozygous S100A4(-/-) mice are fertile, grow normally and exhibit no overt abnormalities; however, the loss of S100A4 results in ...[more]
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